EBOO vs. MAH vs. 10-Pass Ozone: Which Ozone Therapy Is Right for You?

A clear, side-by-side comparison of the most common systemic ozone therapies – how each works, how long it takes, and who it’s best suited for.

Quick Answer: EBOO vs MAH – What's the Difference?

Comparing EBOO vs MAH vs 10-pass ozone? MAH (Major Autohemotherapy) draws a small amount of blood (typically around 100–250 mL), mixes it with medical ozone, and returns it once. Multi-pass or 10-pass ozone repeats that cycle several times in one visit for a higher total dose. EBOO (Extracorporeal Blood Oxygenation and Ozonation) continuously circulates blood outside the body through a specialized filter while ozonating and oxygenating it, treating a much larger volume of blood in a single session. In simple terms: MAH is the gentle foundation, multi-pass steps up the dose, and EBOO is the most comprehensive systemic option.

Side-by-Side Comparison

	MAH	Multi-Pass / 10-Pass	EBOO
How it works	Blood drawn into a sterile bag, ozonated, returned once	Draw-ozonate-return cycle repeated several times	Continuous circulation through a filter with ozone and oxygen
Blood treated	Small volume	Moderate to large volume	Largest volume
Filtration	No	No	Yes
IV access	One IV	One IV	Usually two IVs
Typical treatment time	About 45–60 min	About 60–90 min	About 60–90 min
Often chosen for	First-time ozone, general wellness, maintenance	Stepping up intensity	Deepest systemic support, chronic concerns, full-system reset

Times and volumes are typical ranges and vary by clinic and individual protocol.

MAH (Major Autohemotherapy)

MAH is the most widely studied form of systemic ozone therapy, and much of the published ozone research – including studies in autoimmune conditions – used it. It’s a great entry point for people new to ozone, those who want a lower-intensity option, or clients using ozone for ongoing maintenance.

Multi-Pass and 10-Pass Ozone

Multi-pass protocols repeat the MAH cycle several times in one visit, delivering a larger cumulative ozone exposure without the filtration step. It’s often chosen by people who’ve responded well to MAH and want more intensity.

EBOO: The Most Comprehensive Option

EBOO combines three things in a single session: blood filtration, oxygenation, and precisely dosed ozone exposure, in a continuous closed loop. Because it treats the largest volume of blood, many clients view it as a full-system reset for inflammation and circulation. It’s commonly chosen by people with chronic, complex concerns such as Lyme disease and mold illness, as well as high performers focused on recovery and longevity. Read our complete guide to EBOO therapy for more.

Other Ozone Options at Core IV Therapy

Core IV Therapy offers MAH, High-Dose ozone, multi-pass ozone, insufflation and EBOO, so we can match ozone intensity to your needs rather than steering everyone to one treatment. Ozone can also be paired with IV nutrient therapy, peptides, HBOT, red light therapy and other services in a personalized plan.

Not sure which ozone therapy fits you?

That’s what we’re here for. In a free consultation we’ll compare options based on your health history, goals and budget – and recommend the right starting point.

Prefer to talk now? Call (866) 426-7348 · 108 Elden Street, Suite 15A, Herndon, VA 20170

How to Choose

New to ozone or looking for maintenance? MAH is often the best starting point
Responded well to MAH and want more? Multi-pass is a logical next step
Dealing with a chronic, complex concern or want the most comprehensive session? EBOO is often the choice
Budget matters too: see our transparent EBOO pricing ($1,250–$1,500 per session)
Safety comes first: every option requires screening for contraindications like G6PD deficiency

Learn more about EBOO cost, EBOO safety and candidacy, and what to expect at your first session.

Ozone Therapy Comparison FAQs

What is the difference between EBOO and MAH?

MAH draws a small amount of blood, mixes it with ozone and returns it once. EBOO continuously circulates blood outside the body through a filter while ozonating and oxygenating it, treating a much larger volume in one session. EBOO is more comprehensive; MAH is gentler and has more published research.

Is EBOO better than 10-pass ozone?

Neither is universally better. 10-pass repeats the MAH cycle for a higher cumulative dose, while EBOO adds blood filtration and treats the largest volume of blood. The best choice depends on your health, goals, tolerance and budget.

Which ozone therapy is best for beginners?

MAH is often recommended as a first ozone treatment because it is gentle, well studied and uses a single IV. Some people start directly with EBOO after screening if their goals call for more comprehensive support.

How long does each ozone therapy take?

Typical treatment times are about 45 to 60 minutes for MAH and about 60 to 90 minutes for multi-pass ozone and EBOO, not including check-in and observation. Times vary by protocol.

Find your best ozone option

Schedule a free consultation at Core IV Therapy in Herndon, VA, serving Reston, Ashburn, Sterling, Chantilly, Fairfax, Loudoun and the greater DMV.

Prefer to talk now? Call (866) 426-7348 · 108 Elden Street, Suite 15A, Herndon, VA 20170

Medical Disclaimer: This page is for educational purposes only and is not a substitute for professional medical advice. Ozone therapies are not FDA-approved to diagnose, treat, or cure any disease. Candidacy is determined individually by a qualified provider.